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Over-the-Counter Medications with Acetaminophen Acetaminophen is an active ingredient in more than 200 medications, including popular over-the-counter headache and cold remedies such as DayQuil, NyQuil, Anacin-3, Sudafed, Theraflu, Contac, Benadryl, Zicam and many others. Only one tablespoon of NyQuil or DayQuil contains 325 milligrams of acetaminophen. Since the standard recommended dose of both of these products is two tablespoons, most people will consume 650 mg in a single dose. It is extremely important to take the medication as directed on the package label and not to exceed the recommended dose. *nervous laughter* â¢funny.cO
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